Declinol, a Complex Containing Kudzu, Bitter Herbs Gentian, Tangerine Peeland Bupleurum, Significantly Reduced Alcohol Use Disorders Identification Test AUDIT Scores in Moderate to Heavy Drinkers: A Pilot Study

It’s important to seek AUD treatment only from a qualified healthcare professional or facility. It is often touted as a means of restoring liver health and protecting against liver damage from too much alcohol.

Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY. NPI-031G reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being. Kudzu is a coarse, high-climbing, twining, trailing, perennial vine. The huge root, which can grow to the size of a human, is the source of medicinal preparations used in Traditional Chinese Medicine and modern herbal products. Kudzu grows in most shaded areas in mountains, fields, along roadsides, thickets, and thin forests throughout most of China and the southeastern United States.

Natural Epigenetic-Modifying Molecules in Medical Therapy

Antabuse is not available OTC and requires a prescription from a doctor. People should consult with their doctor to determine if it is the rightdrug for their alcohol dependence.

Available animal https://ecosoberhouse.com/ of the effects of kudzu on alcohol dependence have been reviewed, with plant constituents showing alcohol-suppressing effects in rats. More remedies are needed to help drinkers who overdo it cut down, Penetar says. The medications approved for treating alcohol abuse and dependence don’t work for everyone, he says. A growing number of double-blind, peer reviewed studies have confirmed the effectiveness of using kudzu for alcoholism. Early research focused on rats with good results, which were later replicated with human subjects.

Might help treat alcoholism

And, contrary to disulfiram treatment, the drinking that did occur after kudzu administration did not result in any noxious side effects, increases in subjective ratings of nausea, uncomfortable, or feeling terrible. The reduction in drinking was evident rather quickly as it was apparent for the second through sixth beers and no kudzu-treated participant drank five or six beers, which suggests that binge drinking was curtailed. Our laboratory has been involved in assessing an extract of the kudzu root for its ability to reduce alcohol consumption in humans. In the first, kudzu extract was administered for 7 days and acute binge drinking was suppressed (Lukas et al., 2005). In the second, participants who were treated for 4 weeks with kudzu extract significantly reduced their alcohol consumption during weeks 2 through 4 of the study (Lukas et al., 2013). We have subsequently shown that puerarin is the major active isoflavone because 7 days treatment with this compound alone (1,200 mg/day) produced a similar reduction of binge drinking as the extract (Penetar et al., 2012). All of the above mentioned mechanisms, with the exception of a disulfiram-like one, require repeated administration and time to develop.

Scientists need to do more research on the safe and effective dosages of kudzu root for various uses. Kudzu root is rich in antioxidants, compounds that protect cells from oxidative stress that can lead to disease. The isoflavone puerarin is the most abundant antioxidant compound in the kudzu vine . You may be wondering how people use kudzu root and what to know when considering whether to give it a try.

Kudzu Recovery: My Experience With Kudzu

The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment. Kudzu root has been known for centuries in Traditional Chinese Medicine as ge-gen. The first written mention of the plant as a medicine is in the ancient herbal text of Shen Nong (circa A.D. 100). The historical application for drunkenness has become a major focal point of modern research on kudzu.

• After completion of the program each subject re-took the AUD questionnaire and also filled out an exit interview.
• But it did reduce the number of drinks they had each week by a third to a half.
• In China, the kudzu or gégen is found growing in shaded areas along mountains, in the fields and along roadsides, in thickets and thin forests all over the country.
• Decreased drinking due to ALDH-2 inhibition is attributed to the aversive properties of acetaldehyde accumulated during alcohol consumption.
• Cytisine is a plant-based alkaloid found in the seeds of the golden rain tree .
• The compound puerarin is always found in the highest concentration among all the isoflavones, second is daidzin, followed by daidzein.

Scientists need to do more research on the effects of kudzu root in humans to investigate these effects in the liver. One study in mice found that kudzu vine extract was highly beneficial in treating alcohol-induced liver damage by scavenging harmful free radicals and boosting the natural antioxidant system . For over 2,000 years, people have used kudzu root in traditional Chinese medicine for purposes like treating fevers, diarrhea, and even diabetes and heart disease . If you’re not sure whether kudzu root is right for you, talk with your doctor.

how to reduce alcohol cravings naturally root offered heart-protective benefits to mice with burn-induced heart injuries. People have also used it in traditional Chinese medicine for heart disease, but scientists need to do more research on this .

• Fortunately, there are several medications that can aid in alleviating alcohol cravings.
• Kudzu plant, unlike alcohol medication, produces no effects of its own, does not block the effects of alcohol and does not make people sick if they drink alcohol.
• Hydration and supplementation with B vitamins can be helpful if a person chooses to withdrawal at home.
• Kudzu may also help heavy drinkers cut the amount of alcohol they consume, even if they are not being treated for AUD.
• Another study found that kudzu may really “affect alcohol consumption patterns.” In this same study, people who took an isoflavone extract from the kudzu plant before drinking took longer to reach for the liquor cabinet.
• However, this pilot serves as the basis to further these studies and confirmation in a much larger cohort may have important treatment ramifications for not only alcoholism but possibly RDS behaviors as well.
• Between drinks, the subjects rested their beer on a scale so researchers could monitor exactly how much they were drinking.